課程概述 |
課程大綱:
1、 各種劑型之定義、特性。2、 每一種劑型之基本製備技術,賦型劑、添加劑、安定性、配伍禁忌、儲藏條件、組成設計等之學理、應用及實例。3、 藥典對於各種劑型之製程品管規定。
教材:
1、 American Pharmacy。2、 中華藥典第四版。3、 Remingtons* The Science and Practice of Pharmacy. 18th ed. (1990)或19th ed. (1995)。4、 美國藥典22th ed. (1990)或23th ed. (1995)。
主題:Buffers
Definition
Weak acid/base and their salts
Drug as buffers
pH indicators
Buffer capacity, b
Buffers in pharmaceutical and biological systems
主題:Tonicity and Osmoticity
Osmotic Properties
Isotonicity
Osmolality determination
Method to adjust the tonicity of a solution
主題:Ophthalmic Preparations
Introduction
Types of ophthalmic products and their characteristics
Components in ophthalmic preparations
Potential actives
Inactive ingredients
Antimicrobial preservatives
主題:Sterilization
Introduction
Kinetics of sterilization
Steam (Moist-Heat ) sterilization 高壓蒸氣滅菌法
Dry heat sterilization 乾熱滅菌法
Gas sterilization 氣體滅菌法
Sterilization by filtration 過濾滅菌法
Aseptic working environment
Sterility test and Validation
主題:Parenteral preparations
Introduction
Types of parenteral products
Components and containers
Pyrogens (熱原)
Production procedures
Particulate evaluation
Intravenous fluids & admixtures 靜脈輸注液
Total parenteral nutrition 全靜脈營養輸注液
評分方式:筆試
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